R&D Day Ose Immunotherapeutics 12th of October.
The event has featured presentations by leading clinicians as well as key members of the OSE Immunotherapeutics management team

15 octobre 2021 20 h 39 min
+ de videos

The event, which has feature presentations by leading clinicians as well as key members of the OSE Immunotherapeutics management team, has provided an update on :

• The Company’s strategy to build a leading portfolio of best- and first-in-class cancer immunotherapies.

OSE’s goal to position Tedopi® as a new standard of care in non-small cell lung cancer (NSCLC) after immune checkpoint inhibitor (ICI) failure and its ongoing clinical development as a maintenance therapy for ovarian and pancreatic cancers.

• Recent clinical data supporting development of first-in-class CD47/SIRPα pathway targeting antibody BI 765063 alone and in combination with anti-PD-1 ezabenlimab in solid tumours.

• OSE’s emerging best- and first-in-class immuno-oncology portfolio which includes a novel myeloid cell “Don’t Eat Me” signal targeting CLEC-1 and a bispecific antibody platform (BiCKI®) whose first candidate, BiCKI®-IL-7 both combines an anti-PD-1 and the cytokine signal interleukin-7 (IL-7).

Amongst the R&D Day’s key speakers are:

Pr. Benjamin Besse, Director of Clinical Research at Gustave Roussy (Villejuif, France), who has presented the positive final results of the Phase 3 Tedopi® clinical program in NSCLC, called Atalante-1, as well as an overview of the current landscape in NSCLC post-ICI.

Dr. Philippe Cassier, Medical Oncologist at Leon Berard




ABOUT OSE Immunotherapeutics :

OSE Immunotherapeutics is an integrated biotechnology company focused on developing and partnering therapies to control the immune system for immuno-oncology and autoimmune diseases. The company’s immunology research and development platform is focused on three areas: T-cell-based vaccination, Immuno-Oncology (focus on myeloid targets), Auto-immunity & Inflammation. Its balanced first-in-class clinical and preclinical portfolio has a diversified risk profile: Vaccine platform – Tedopi® (innovative combination of neoepitopes): the company’s most advanced product; positive final results of the Phase 3 trial (Atalante 1) in Non-Small Cell Lung Cancer patients after secondary resistance to checkpoint inhibitors. In Phase 2 in pancreatic cancer (TEDOPaM), sponsor GERCOR. In Phase 2 in ovary cancer, in combination with pembrolizumab (TEDOVA), sponsor ARCAGY-GINECO. In Phase 2 in non-small cell lung cancer in combination with nivolumab, sponsor Italian foundation FoRT. – CoVepiT: a prophylactic second-generation vaccine against COVID-19, developed using SARS-CoV-2 optimized epitopes against multi variants. Positive preclinical and human ex vivo results. Voluntary and temporary Phase 1 enrollment suspension on-going (July 2021). Immuno-oncology platform – BI 765063 (OSE-172, anti-SIRPα mAb on CD47/SIRPα pathway): developed in partnership with Boehringer Ingelheim in advanced solid tumors; positive Phase 1 dose escalation results of BI 765063 in monotherapy or in combination with ezabenlimab (PD-1 antagonist); Expansion Phase 1 open for screening. – CLEC-1 (novel myeloid checkpoint target): identification of mAb antagonists of CLEC-1 blocking the “Don’t Eat Me” signal that increase both tumor cell phagocytosis by macrophages and antigen capture by dendritic cells. – BiCKI®: bispecific fusion protein platform built on the key backbone component anti-PD-1 (OSE-279) combined with new immunotherapy targets; 2nd generation of PD-(L)1 inhibitors to increase antitumor efficacity. Auto-immunity and inflammation platform – FR104 (anti-CD28 monoclonal antibody): Licensing partnership agreement with Veloxis in the organ transplant market; ongoing Phase 1/2 in renal transplant (sponsored by the Nantes University Hospital); Phase 2-ready asset in an autoimmune disease indication. – OSE-127/S95011 (humanized monoclonal antibody targeting IL-7 receptor): developed in partnership with Servier; positive Phase 1 results; in Phase 2 in ulcerative colitis (OSE sponsor) and an independent Phase 2a is being conducted in Sjögren’s syndrome (Servier sponsor). – OSE-230 (ChemR23 agonist mAb): first-in-class therapeutic agent with the potential to resolve chronic inflammation by driving affected tissues to tissue integrity. For more information: https://ose-immuno.com/en/

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